Lewis knew they were deep in Blackfeet homeland, and staying there was risky. The day after leaving Camp Disappointment, his small group met eight young Blackfeet (Piikani) men near today?s Two Medicine River, and they agreed to camp together for the night. During their talks, Lewis explained that Americans planned to trade with many tribes on the Missouri, including enemies of the Blackfeet?an idea that likely worried the Blackfeet about losing control of their powerful horse and gun trade. Early the next morning a struggle broke out over the expedition?s guns and horses; in the fight that followed, two Blackfeet men were shot and killed, in what Lewis later described as self?defense, and his party fled more than 100 miles before stopping again. This ?Two Medicine Fight? is remembered as the only time on the entire Lewis and Clark Expedition when people on either side died in a violent clash.